Projects
Projects: Projects for Investigator |
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| Reference Number | BB/D522511/1 | |
| Title | Dissection and exploitation of xyloglucanases | |
| Status | Completed | |
| Energy Categories | Renewable Energy Sources(Bio-Energy, Production of other biomass-derived fuels (incl. Production from wastes)) 50%; Renewable Energy Sources(Bio-Energy, Production of transport biofuels (incl. Production from wastes)) 50%; |
|
| Research Types | Basic and strategic applied research 100% | |
| Science and Technology Fields | PHYSICAL SCIENCES AND MATHEMATICS (Chemistry) 100% | |
| UKERC Cross Cutting Characterisation | Not Cross-cutting 100% | |
| Principal Investigator |
Prof G (Gideon ) Davies No email address given Chemistry University of York |
|
| Award Type | Research Grant | |
| Funding Source | BBSRC | |
| Start Date | 01 December 2005 | |
| End Date | 30 November 2008 | |
| Duration | 36 months | |
| Total Grant Value | £225,495 | |
| Industrial Sectors | Transport Systems and Vehicles | |
| Region | Yorkshire & Humberside | |
| Programme | ||
| Investigators | Principal Investigator | Prof G (Gideon ) Davies , Chemistry, University of York (99.999%) |
| Other Investigator | Prof KS (Keith ) Wilson , Chemistry, University of York (0.001%) |
|
| Web Site | ||
| Objectives | Objectives not supplied | |
| Abstract | The plant cell wall is a composite structure. Its most well characterised component is cellulose, whose loads-bearing fibres provide strength whilst maintaining flexibility. The long beta-1,4 glucan polymers form microcrystalline arrays stabilised by extensive intra and inter-chain hydrogen bonding. In vivo, the cellular chains are embedded in a mesh of hemicelluloses and lignin whose composition varies between, and defines, the different cell types. One of the key interactions of the cellulosic microfibrils, however, is their intimate relationship with xyloglucan: a branched polysaccharide which has recently been used to modify cellulosic materials for industrial applications. Here we will study nature¿s breakdown system for xyloglucan, xyloglucanases, with a view to dissecting and exploiting their subsite structure both for xyloglucan hydrolysis and the synthesis of novel tailored composites. The work will involve kinetic description on specifically-synthesised aryl-xyloglucan oligosaccharides, 3-D structure determination of three different xyloglucanases (a previously un-analysed enzyme class) and the exploration and exploitation of these enzymes and their mutants for the synthesis of novel oligosaccharides and cellulosic composites. | |
| Publications | (none) |
|
| Final Report | (none) |
|
| Added to Database | 22/11/13 | |
